Bubbly

Pustular ulcer is a chronic autoimmune disease characterized by the appearance of a special kind of blisters on the surface of previously healthy skin and mucous membranes. The types of vesicles include vulgar, vegetative, erythematous, and sheet-like.
Vesicles can be diagnosed if acantholytic cells are detected in a swab or in the vesicles in the epidermis itself (histological examination). Glucocorticosteroids are used first for the treatment of vesicles (a whole course of administration is prescribed). The latter is always well combined with extracorporeal hemocorrection (plasmaphoresis, cryoapherosis, hemosorption). Some doctors choose this drug: https://pillintrip.com/medicine/lepicortinolo.

What is it?
Pustular ulcer is a severe disease that affects the human skin. As a result of its progression, pathological blisters are formed on the skin and mucous membranes, inside filled with exudate. This process begins because of the separation of the epithelium. Pathological foci may merge and tend to grow rapidly.

Causes of occurrence
The causes of the development of vesicles have not yet been definitively studied. One of the main causes of vesicles is a disruption of autoimmune processes, thereby for the immune system cells become antibodies.

The disruption of cell structure falls under the influence of external factors, as well as aggressive environmental conditions. As a result, the communication between the cells is disrupted, leading to the formation of blisters. The incidence rate in people with a hereditary predisposition is much higher.

Mechanism of blister formation
Human skin can be figuratively described as a water-spring “mattress”, covered with a kind of “wall”. In the formation of bubbles “mattress” is not involved – it suffers only the top layer, the epidermis.

It consists of an epidermal layer of 10-20 cellular layers, which look like bricks under the microscope. “Bricks” of the second layer of epidermis are connected to each other by peculiar “bridges”. On top of the “wall” are layers of cells that no longer quite look like cells, resembling applied cream. These are the scales, the corneocytes, necessary for protection against mechanical, chemical and physical damage.

If, under the influence of internal or external causes, antibodies are formed that destroy the “bridges”-desmosomes between the cells of the basal layer (this is called acantholysis and can be seen under a microscope), it is a true vesicular disease. If the tissue fluid penetrates between the basal and upper epidermal layers without destroying the bridges, it is pemphigoid. Viral vesicular disease also occurs without destruction of the desmosomes.

Symptoms
Given that experts have identified several different types of this pathology, the symptoms in each of them will be very specific. Of course, there are also a number of common trends and signs inherent in all types of the disease. These may include, for example, a wave-like course of the pathological process.

Periods of exacerbation alternate with a transition to a calmer stage, when the main symptoms subside or disappear altogether. An important factor for the patient will be the fact that in the absence of timely diagnosis and prescription of effective treatment, there is a great risk of developing severe conditions, aggravated by concomitant diseases.

The presence of crusts, ranging from pale pink soft to red dense, resembling tetter;
There is a deterioration in the general condition;
A decrease in the body’s immune response;
Formation of blisters of varying density;
Also with a severe course there is a separation of layers of the epidermis, and it can occur both in the lesion and away from it.
Damage and ulceration of the mucous membrane of the mouth, nasopharynx or genitals;
Pain with the act of swallowing or eating;
Bad breath, indicating mucous membrane involvement;
Hyper-salivation or, in other words, increased salivation;
In the seborrheic form, the scalp presents with yellowish or brownish crusts.
The blisters vary in appearance from flat to thin-walled, which burst if touched lightly. Erosion and, later, crusts form in their place.
In a severe course, the formation of eroded skin surface in place of the blisters is possible. Their peculiarity becomes a tendency of peripheral growth. Over time, such erosions occupy a large surface of the skin, causing pain and discomfort to the patient.
In children, manifestations of vesicles are localized over the entire surface of the skin, including the extremities.
Specialists say that in this disease can be noted as a pure form of the pathological process, and mixed, smoothly passing one into the other. Consequently, the symptoms and signs of vesicles in a particular person may vary and indicate the presence of several types of the disease.